abstract：OBJECTIVE:To investigate the effect of two different food supplements on body mass index (BMI) in wasted Malawian adults with HIV who were starting antiretroviral therapy. DESIGN:Randomised, investigator blinded, controlled trial. SETTING:Large, public clinic associated with a referral hospital in Blantyre, Malawi. ...

journal_title：BMJ (Clinical research ed.)

authors： Ndekha MJ,van Oosterhout JJ,Zijlstra EE,Manary M,Saloojee H,Manary MJ

更新日期：2009-05-22 00:00:00

abstract：OBJECTIVE:To determine the incidence of cervical cancer after several negative cervical smear tests at different ages. DESIGN:Prospective observational study of incidence of cervical cancer after the third consecutive negative result based on individual level data in a national registry of histopathology and cytopatho...

journal_title：BMJ (Clinical research ed.)

authors： Rebolj M,van Ballegooijen M,Lynge E,Looman C,Essink-Bot ML,Boer R,Habbema D

更新日期：2009-04-24 00:00:00

abstract：OBJECTIVE:To identify modifiable factors that influence relatives' decision to allow organ donation. DESIGN:Systematic review. DATA SOURCES:Medline, Embase, and CINAHL, without language restriction, searched to April 2008. Review methods Three authors independently assessed the eligibility of the identified studies. ...

journal_title：BMJ (Clinical research ed.)

authors： Simpkin AL,Robertson LC,Barber VS,Young JD

更新日期：2009-04-21 00:00:00

abstract：OBJECTIVES:To elucidate current trends and geographical patterns in the sex ratio at birth and in the population aged under 20 in China and to determine the roles played by sex selective abortion and the one child policy. DESIGN:Analysis of household based cross sectional population survey done in November 2005. SETT...

journal_title：BMJ (Clinical research ed.)

authors： Zhu WX,Lu L,Hesketh T

更新日期：2009-04-09 00:00:00

abstract：OBJECTIVE:To assess the effects of social deprivation on survival after cardiac surgery and to examine the influence of potentially modifiable risk factors. DESIGN:Analysis of prospectively collected data. Prognostic models used to examine the additional effect of social deprivation on the end points. SETTING:Birming...

journal_title：BMJ (Clinical research ed.)

authors： Pagano D,Freemantle N,Bridgewater B,Howell N,Ray D,Jackson M,Fabri BM,Au J,Keenan D,Kirkup B,Keogh BE,Quality and Outcomes Research Unit (QuORU) UHB Birmingham.,North West Quality Improvement Programme in Cardiac Interventions (U

更新日期：2009-04-02 00:00:00

abstract：OBJECTIVE:To investigate the association between tea drinking habits in Golestan province, northern Iran, and risk of oesophageal squamous cell carcinoma. DESIGN:Population based case-control study. In addition, patterns of tea drinking and temperature at which tea was drunk were measured among healthy participants in...

journal_title：BMJ (Clinical research ed.)

authors： Islami F,Pourshams A,Nasrollahzadeh D,Kamangar F,Fahimi S,Shakeri R,Abedi-Ardekani B,Merat S,Vahedi H,Semnani S,Abnet CC,Brennan P,Møller H,Saidi F,Dawsey SM,Malekzadeh R,Boffetta P

更新日期：2009-03-26 00:00:00

abstract：OBJECTIVE:To determine cancer morbidity in members of the armed forces who took part in tests of chemical warfare agents from 1941 to 1989. DESIGN:Historical cohort study, with cohort members followed up to December 2004. DATA SOURCE:Archive of UK government research facility at Porton Down, UK military personnel rec...

journal_title：BMJ (Clinical research ed.)

authors： Carpenter LM,Linsell L,Brooks C,Keegan TJ,Langdon T,Doyle P,Maconochie NE,Fletcher T,Nieuwenhuijsen MJ,Beral V,Venables KM

更新日期：2009-03-24 00:00:00

abstract：OBJECTIVES:To determine whether informed consent introduces selection bias in prospective observational studies using data from medical records, and consent rates for such studies. DESIGN:Systematic review. DATA SOURCES:Embase, Medline, and the Cochrane Library up to March 2008, reference lists from pertinent article...

journal_title：BMJ (Clinical research ed.)

authors： Kho ME,Duffett M,Willison DJ,Cook DJ,Brouwers MC

更新日期：2009-03-12 00:00:00

abstract：OBJECTIVE:To evaluate the incidence of serious maternal complications after the use of various tocolytic drugs for the treatment of preterm labour in routine clinical situations. DESIGN:Prospective cohort study. SETTING:28 hospitals in the Netherlands and Belgium. PARTICIPANTS:1920 consecutive women treated with toc...

journal_title：BMJ (Clinical research ed.)

authors： de Heus R,Mol BW,Erwich JJ,van Geijn HP,Gyselaers WJ,Hanssens M,Härmark L,van Holsbeke CD,Duvekot JJ,Schobben FF,Wolf H,Visser GH

更新日期：2009-03-05 00:00:00

abstract：OBJECTIVE:To investigate the differences between skeletal and chronological age and to assess the role of maturity status, anthropometric data, and football related variables in explaining injury statistics in elite schoolboy footballers. DESIGN:Prospective study of injuries in schoolboy footballers according to skele...

journal_title：BMJ (Clinical research ed.)

authors： Johnson A,Doherty PJ,Freemont A

更新日期：2009-02-26 00:00:00

abstract：OBJECTIVE:To investigate the association between treatment induced change in high density lipoprotein cholesterol and total death, coronary heart disease death, and coronary heart disease events (coronary heart disease death and non-fatal myocardial infarction) adjusted for changes in low density lipoprotein cholestero...

journal_title：BMJ (Clinical research ed.)

authors： Briel M,Ferreira-Gonzalez I,You JJ,Karanicolas PJ,Akl EA,Wu P,Blechacz B,Bassler D,Wei X,Sharman A,Whitt I,Alves da Silva S,Khalid Z,Nordmann AJ,Zhou Q,Walter SD,Vale N,Bhatnagar N,O'Regan C,Mills EJ,Bucher HC,M

更新日期：2009-02-16 00:00:00

abstract：OBJECTIVE:To assess the effectiveness of an antenatal service using community based breastfeeding peer support workers on initiation of breast feeding. DESIGN:Cluster randomised controlled trial. SETTING:Community antenatal clinics in one primary care trust in a multiethnic, deprived population. PARTICIPANTS:66 ante...

journal_title：BMJ (Clinical research ed.)

authors： MacArthur C,Jolly K,Ingram L,Freemantle N,Dennis CL,Hamburger R,Brown J,Chambers J,Khan K

更新日期：2009-01-30 00:00:00

abstract：OBJECTIVE:To assess evidence from randomised clinical trials about the effectiveness of extracts of Boswellia serrata (frankincense). DESIGN:Systematic review. DATA SOURCES:Electronic searches on Medline, Embase, Cinahl, Amed, and Cochrane Library. Hand searches of conference proceedings, bibliographies, and departme...

journal_title：BMJ (Clinical research ed.)

authors： Ernst E

更新日期：2008-12-17 00:00:00

abstract：OBJECTIVE:To determine medical students' self awareness and ability to discriminate right from left; to identify characteristics associated with this ability; and to identify any techniques used to aid discrimination. DESIGN:Questionnaire and psychometric study. SETTING:Undergraduate medical school, Northern Ireland....

journal_title：BMJ (Clinical research ed.)

authors： Gormley GJ,Dempster M,Best R

更新日期：2008-12-16 00:00:00

abstract：OBJECTIVES:To report the sensitivities of the faecal occult blood test, screening episode, and screening programme for colorectal cancer and the benefits of applying a randomised design at the implementation phase of a new public health policy. DESIGN:Experimental design incorporated in public health evaluation using ...

journal_title：BMJ (Clinical research ed.)

authors： Malila N,Oivanen T,Malminiemi O,Hakama M

更新日期：2008-11-20 00:00:00

abstract：OBJECTIVE:To investigate the impact of coexistent psychiatric morbidity on risk of suicide after a suicide attempt. DESIGN:Cohort study with follow-up for 21-31 years. SETTING:Swedish national register based study. PARTICIPANTS:39 685 people (53% women) admitted to hospital for attempted suicide during 1973-82. MAI...

journal_title：BMJ (Clinical research ed.)

authors： Tidemalm D,Långström N,Lichtenstein P,Runeson B

更新日期：2008-11-18 00:00:00

abstract：OBJECTIVE:To examine the impact of antenatal supplementation with multiple micronutrients or iron and folic acid compared with folic acid alone on birth weight, duration of gestation, and maternal haemoglobin concentration in the third trimester. DESIGN:Cluster randomised double blind controlled trial. SETTING:Two ru...

journal_title：BMJ (Clinical research ed.)

authors： Zeng L,Dibley MJ,Cheng Y,Dang S,Chang S,Kong L,Yan H

更新日期：2008-11-07 00:00:00

abstract：OBJECTIVE:To identify major concerns of national and local importance in the provision, commissioning, research, and use of generalist end of life care. DESIGN:A national consultation and prioritising exercise using a modified form of the nominal group technique. PARTICIPANTS:Healthcare practitioners, commissioners, ...

journal_title：BMJ (Clinical research ed.)

authors： Shipman C,Gysels M,White P,Worth A,Murray SA,Barclay S,Forrest S,Shepherd J,Dale J,Dewar S,Peters M,White S,Richardson A,Lorenz K,Koffman J,Higginson IJ

更新日期：2008-10-01 00:00:00

abstract：OBJECTIVE:To investigate whether paracetamol (acetaminophen) plus ibuprofen are superior to either drug alone for increasing time without fever and the relief of fever associated discomfort in febrile children managed at home. DESIGN:Individually randomised, blinded, three arm trial. SETTING:Primary care and househol...

journal_title：BMJ (Clinical research ed.)

authors： Hay AD,Costelloe C,Redmond NM,Montgomery AA,Fletcher M,Hollinghurst S,Peters TJ

更新日期：2008-09-02 00:00:00

abstract：OBJECTIVE:To assess the impact of Stepping Stones, a HIV prevention programme, on incidence of HIV and herpes simplex type 2 (HSV-2) and sexual behaviour. DESIGN:Cluster randomised controlled trial. SETTING:70 villages (clusters) in the Eastern Cape province of South Africa. PARTICIPANTS:1360 men and 1416 women aged...

journal_title：BMJ (Clinical research ed.)

authors： Jewkes R,Nduna M,Levin J,Jama N,Dunkle K,Puren A,Duvvury N

更新日期：2008-08-07 00:00:00

abstract：OBJECTIVE:To examine how much oncologists tell patients about the survival benefit of palliative chemotherapy during consultations at which decisions about treatment are made. DESIGN:Qualitative study in which consultations were observed and digitally recorded. SETTING:Teaching hospital and district general hospital ...

journal_title：BMJ (Clinical research ed.)

authors： Audrey S,Abel J,Blazeby JM,Falk S,Campbell R

更新日期：2008-07-31 00:00:00

abstract：OBJECTIVE:To examine the protective efficacy of measles vaccination in infants in a low income country before 9 months of age. DESIGN:Randomised clinical trial. PARTICIPANTS:1333 infants aged 4.5 months: 441 in treatment group and 892 in control group. SETTING:Urban area in Guinea-Bissau. INTERVENTION:Measles vacci...

journal_title：BMJ (Clinical research ed.)

authors： Martins CL,Garly ML,Balé C,Rodrigues A,Ravn H,Whittle HC,Lisse IM,Aaby P

更新日期：2008-07-24 00:00:00

abstract：OBJECTIVE:To assess the association between genitourinary infections in the month before conception to the end of the first trimesterand gastroschisis. DESIGN:Case-control study with self reported infections from a computer assisted telephone interview. SETTING:National birth defects prevention study, a multisite, po...

journal_title：BMJ (Clinical research ed.)

authors： Feldkamp ML,Reefhuis J,Kucik J,Krikov S,Wilson A,Moore CA,Carey JC,Botto LD

更新日期：2008-06-21 00:00:00

abstract：OBJECTIVE:To examine the effectiveness of parenteral corticosteroids for the relief of acute severe migraine headache and prevention of recurrent headaches. DESIGN:Meta-analysis. DATA SOURCES:Electronic databases (Cochrane Central Register of Controlled Trials, Medline, Embase, LILACS, and CINAHL), conference proceed...

journal_title：BMJ (Clinical research ed.)

authors： Colman I,Friedman BW,Brown MD,Innes GD,Grafstein E,Roberts TE,Rowe BH

更新日期：2008-06-14 00:00:00

abstract：OBJECTIVE:To compare four potential screening strategies, and subsequent interventions, for the prevention and treatment of type 2 diabetes: (a) screening for type 2 diabetes to enable early detection and treatment, (b) screening for type 2 diabetes and impaired glucose tolerance, intervening with lifestyle interventio...

journal_title：BMJ (Clinical research ed.)

authors： Gillies CL,Lambert PC,Abrams KR,Sutton AJ,Cooper NJ,Hsu RT,Davies MJ,Khunti K

更新日期：2008-05-24 00:00:00

abstract：OBJECTIVE:To compare health behaviours during pregnancy (smoking and alcohol consumption) and after birth (initiation and duration of breast feeding) between British/Irish white mothers and mothers from ethnic minority groups; and, in mothers from ethnic minority groups, to examine whether indicators of acculturation (...

journal_title：BMJ (Clinical research ed.)

authors： Hawkins SS,Lamb K,Cole TJ,Law C,Millennium Cohort Study Child Health Group.

更新日期：2008-05-10 00:00:00

abstract：OBJECTIVE:To use funnel plots and cumulative funnel plots to compare in-hospital outcome data for operators undertaking percutaneous coronary interventions with predicted results derived from a validated risk score to allow for early detection of variation in performance. DESIGN:Analysis of prospectively collected dat...

journal_title：BMJ (Clinical research ed.)

authors： Kunadian B,Dunning J,Roberts AP,Morley R,Twomey D,Hall JA,Sutton AG,Wright RA,Muir DF,de Belder MA

更新日期：2008-04-26 00:00:00

abstract：OBJECTIVES:To assess aspects of the internal validity of recently published cluster randomised trials and explore the reporting of information useful in assessing the external validity of these trials. DESIGN:Review of 34 cluster randomised trials in primary care published in 2004 and 2005 in seven journals (British M...

journal_title：BMJ (Clinical research ed.)

authors： Eldridge S,Ashby D,Bennett C,Wakelin M,Feder G

更新日期：2008-04-19 00:00:00

abstract：OBJECTIVE:To assess the safety and effectiveness of eflornithine as first line treatment for human African trypanosomiasis. DESIGN:Cohort study. SETTING:Control programme in Ibba, southern Sudan. PARTICIPANTS:1055 adults and children newly diagnosed with second stage disease in a 16 month period. MAIN OUTCOME MEASU...

journal_title：BMJ (Clinical research ed.)

authors： Priotto G,Pinoges L,Fursa IB,Burke B,Nicolay N,Grillet G,Hewison C,Balasegaram M

更新日期：2008-03-29 00:00:00

abstract：OBJECTIVES:To assess whether supplementation with antioxidants, folinic acid, or both improves the psychomotor and language development of children with Down's syndrome. DESIGN:Randomised controlled trial with two by two factorial design. SETTING:Children living in the Midlands, Greater London, and the south west of ...

journal_title：BMJ (Clinical research ed.)

authors： Ellis JM,Tan HK,Gilbert RE,Muller DP,Henley W,Moy R,Pumphrey R,Ani C,Davies S,Edwards V,Green H,Salt A,Logan S

更新日期：2008-03-15 00:00:00

abstract：OBJECTIVE:To examine whether the association of inadequate or unclear allocation concealment and lack of blinding with biased estimates of intervention effects varies with the nature of the intervention or outcome. DESIGN:Combined analysis of data from three meta-epidemiological studies based on collections of meta-an...

journal_title：BMJ (Clinical research ed.)

authors： Wood L,Egger M,Gluud LL,Schulz KF,Jüni P,Altman DG,Gluud C,Martin RM,Wood AJ,Sterne JA

更新日期：2008-03-15 00:00:00

abstract：OBJECTIVE:Rapid diagnostic tests for malaria seem cost effective in standard analyses, but these do not take account of clinicians' response to test results. This study tested the impact of clinicians' response to rapid diagnostic test or microscopy results on the costs and benefits of testing at different levels of ma...

journal_title：BMJ (Clinical research ed.)

authors： Lubell Y,Reyburn H,Mbakilwa H,Mwangi R,Chonya S,Whitty CJ,Mills A

更新日期：2008-01-26 00:00:00

abstract：OBJECTIVE:To investigate the association between elective caesarean sections and neonatal respiratory morbidity and the importance of timing of elective caesarean sections. DESIGN:Cohort study with prospectively collected data from the Aarhus birth cohort, Denmark. SETTING:Obstetric department and neonatal department...

journal_title：BMJ (Clinical research ed.)

authors： Hansen AK,Wisborg K,Uldbjerg N,Henriksen TB

更新日期：2008-01-12 00:00:00

abstract：OBJECTIVE:To compare the functional results after displaced fractures of the femoral neck treated with internal fixation or hemiarthroplasty. DESIGN:Randomised trial with blinding of assessments of functional results. SETTING:University hospital. PARTICIPANTS:222 patients; 165 (74%) women, mean age 83 years. Inclusi...

journal_title：BMJ (Clinical research ed.)

authors： Frihagen F,Nordsletten L,Madsen JE

更新日期：2007-12-15 00:00:00

abstract：OBJECTIVE:To review the evidence base from randomised controlled trials of combined cardiac resynchronisation therapy and implantable cardioverter defibrillator therapy in left ventricular impairment and symptomatic heart failure. DESIGN:Bayesian network meta-analysis. DATA SOURCES:Medline, Embase, and Cochrane datab...

journal_title：BMJ (Clinical research ed.)

authors： Lam SK,Owen A

更新日期：2007-11-03 00:00:00

abstract：OBJECTIVE:To evaluate the effectiveness of dietary antioxidants in the primary prevention of age related macular degeneration (AMD). DESIGN:Systematic review and meta-analysis. DATA SOURCES:Search of seven databases without limits on year or language of publication, and retrieval of references in pertinent reviews an...

journal_title：BMJ (Clinical research ed.)

authors： Chong EW,Wong TY,Kreis AJ,Simpson JA,Guymer RH

更新日期：2007-10-13 00:00:00

abstract：OBJECTIVE:To examine the absolute risks or benefits on cancer associated with oral contraception, using incident data. DESIGN:Inception cohort study. SETTING:Royal College of General Practitioners' oral contraception study. PARTICIPANTS:Directly standardised data from the Royal College of General Practitioners' oral...

journal_title：BMJ (Clinical research ed.)

authors： Hannaford PC,Selvaraj S,Elliott AM,Angus V,Iversen L,Lee AJ

更新日期：2007-09-29 00:00:00

abstract：OBJECTIVES:To provide insight into factors that contribute to the anxiety reported in a quantitative study of the psychological effect of screening for type 2 diabetes. To explore expectations of and reactions to the screening experience of patients with positive, negative, and intermediate results. DESIGN:Prospective...

journal_title：BMJ (Clinical research ed.)

authors： Eborall H,Davies R,Kinmonth AL,Griffin S,Lawton J

更新日期：2007-09-08 00:00:00

abstract：OBJECTIVE:To compare the efficacy of five probiotic preparations recommended to parents in the treatment of acute diarrhoea in children. Design Randomised controlled clinical trial in collaboration with family paediatricians over 12 months. SETTING:Primary care. PARTICIPANTS:Children aged 3-36 months visiting a famil...

journal_title：BMJ (Clinical research ed.)

authors： Canani RB,Cirillo P,Terrin G,Cesarano L,Spagnuolo MI,De Vincenzo A,Albano F,Passariello A,De Marco G,Manguso F,Guarino A

更新日期：2007-08-18 00:00:00

abstract：OBJECTIVE:To determine the efficacy of a probiotic drink containing Lactobacillus for the prevention of any diarrhoea associated with antibiotic use and that caused by Clostridium difficile. DESIGN:Randomised double blind placebo controlled study. PARTICIPANTS:135 hospital patients (mean age 74) taking antibiotics. E...

journal_title：BMJ (Clinical research ed.)

authors： Hickson M,D'Souza AL,Muthu N,Rogers TR,Want S,Rajkumar C,Bulpitt CJ

更新日期：2007-07-14 00:00:00